About this episode
If you heard about miraculous CAR-T cell therapies that cure cancer in one go, my guest today works on something one step further: immunotherapies that are manufactured from healthy donor cells. That means a thousand cancer patients may receive in the future a life-saving shot manufactured ahead and administered when needed.You may expect a fascinating journey into off-the-shelf cell immune therapies of the futurehow the HIV virus works and how understanding this is key to the novel therapythe difference between gene editing and gene engineeringwhat is gene silencingwhat is microRNAand how to administer immune cells from a donor without creating immunowarsDr. Marco Alessandrini is the CEO of Antion Biosciences. A biochemist and molecular biologist who aims to democratize access to mind-boggling (and very expensive now) cell therapies. A seasoned researcher who beautifully talks about gene and cell engineering.Antion Biosciences is a Swiss biotech startup developing novel gene and gene-modified therapies thanks to a proprietary multiplex cell engineering platform. Their miCAR T cells are manufactured – hold your breath – from a healthy donor to treat a thousand cancer patients. They are at the beginning of this very promising journey. Follow it on:https://antionbio.comTimestamps:0:00 Dr. Marco Alessandrini and Antion Biosciences1:24 Donor Cell Therapies for Haematological Cancer Patients: T-Cell Malignancies3:09 What Are Cell Therapies, Gene-Modified Cell Therapies, Gene Therapies7:22 The Kiss-And-Kill Effect of T-Cells, CAR-T Cells13:55 The Limits of Autologous Cell Therapies16:34 Off-the-Shelf Allogenic Cell Therapies: How to Engineer T-Cells21:52 How HIV Virus Works26:25 What is MicroRNA and How to Use It31:35 Why to Suppress Genes in Cell and Gene Therapies37:08 The Berlin Patient – the Only Person Cured of HIV, and Gene Suppressing45:16 Transitioning from Academia to Biotech49:35 Researching and Improving MicroRNA Technology for Many Other Diseases and Conditions54:08 Thank You, Follow Antion Biosciences55:19 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
