About this episode
A drug that works for a mouse might not work for a human. How about testing drugs for inflammatory diseases – and cosmetics – on human organoids? You’ll hear what are human vascular organoidsand how to grow human cellsalso about the mechanisms of inflammation and the ability to see where drugs can block itarthritis and other chronic inflammatory diseasespersonalized medicinecosmetics not tested on animalsa terrifying process of founding a startupa death, a theft, a fire, and an obsessive mindset that kept the lab standingDr. Paul Bradfield is a scientist turned an efficient CEO. An expert in drug development and assay development, he has specialized in inflammatory diseases. After laboratory head at Merck Serono, he took an entrepreneurship path and founded MessenFlow.MessenFlow is a Swiss scale-up that has developed a platform for animal-free accelerated drug and cosmetics development. Their human tissue engineering system mimics human inflammation and allows us to, literally, see the movement of leukocytes in blood vessels.Here are more details about what the lab can do:http://mesenflow.comTimestamps:0:00 Dr. Paul Bradfield and MesenFlow1:12 What Are Organoids4:59 Limits of Today's Pre-clinical Drug and Cosmetic Testing on Mouse Models10:45 How to Build a System That Works Like a Human Inflammatory Pathology14:57 Organoids for Chronic Inflammatory Diseases16:48 Vascular Organoids and Recording White Blood Vessels Move25:26 Testing a Drug on a Human Organoid Blood System29:03 Organoids for Personalized Medicine31:04 What's Leukocyte Recruitment and Transmigration36:13 What's the Higher Throughpu38:27 Pushed from Science to Disruptive Biotech Startup47:20 Organoids for Cosmetics Testing50:26 Terrifying Bootstrapped Startup Beginnings and Challenges57:01 Scaling Up in the Field of Organoid Drug and Cosmetics Testing59:58 Thank You, Follow MesenFlow1:00:27 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
