About this episode
We dive into the recognition and management of blast crisis.
Hosts:
Sadakat Chowdhury, MD
Brian Gilberti, MD
https://media.blubrry.com/coreem/content.blubrry.com/coreem/Blast_Crisis.mp3
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Tags: Hematology, Oncology
Show Notes
Topic Overview
Blast crisis is an oncologic emergency, most commonly seen in chronic myeloid leukemia (CML).
Defined by:
>20% blasts in peripheral blood or bone marrow.
May include extramedullary blast proliferation.
Without treatment, median survival is only 3–6 months.
Pathophysiology & Associated Conditions
Usually occurs in CML, but also in:
Myeloproliferative neoplasms (MPNs)
Myelodysplastic syndromes (MDS)
